AP4 Transcription Factor Binding Site is a Repressor Element in ek2 Promoter of Human Liver Carcinoma Cell Line, HepG2

Down Regulation of DHFR Promoter Activity by PML Transcription Repressor

Toxicity Effect of Silver Nanoparticles on Mice Liver Primary Cell Culture and HepG2 Cell Line

Nano-silver (AgNP) has biological properties which are significant for consumer products, food technology, textiles and medical applications (e.g. wound care products, implantable medical devices, in diagnosis, drug delivery, and imaging). For their antibacterial activity, silver nanoparticles are largely used in various commercially available products. Thus, the use of nano-silver is becoming ...

Toxicity Effect of Silver Nanoparticles on Mice Liver Primary Cell Culture and HepG2 Cell Line

Nano-silver (AgNP) has biological properties which are significant for consumer products, food technology, textiles and medical applications (e.g. wound care products, implantable medical devices, in diagnosis, drug delivery, and imaging). For their antibacterial activity, silver nanoparticles are largely used in various commercially available products. Thus, the use of nano-silver is becoming ...

CpG site methylation in CRYAA promoter affect transcription factor Sp1 binding in human lens epithelial cells

BACKGROUND Age-related cataract (ARC) is the leading cause of visual impairment worldwide, and α-crystallin (CRYAA) is the predominant structural protein involved in the maintenance of lens clarity and refractive properties. We previously demonstrated that CRYAA genes undergo epigenetic repression in the lens epithelia in ARC. We further analyze the underlying mechanism in the current study. ...

Inhibition of Immune System by an Immunosuppressive Factor from a Human Prostatic Carcinoma Cell Line (JCA-1)

Prostatic carcinoma is the most commonly diagnosed tumor among men over 40 which results in over 30,000 deaths each year in the United States. Previous studies indicated that tumor cell lines produce and release several growth regulatory factors into their condition media and so far a number of human tumor cell-derived suppressor factors have been isolated that affect normal immune functions. I...